MitoCare

Mitochondria are the organelles inside cells that produce energy. Mitochondria have a number of roles in the body. Primarily, they are cellular “fuel stations” responsible for supplying greater than 95% of the body’s energy needs. Mitochondrial growth is the process by which new mitochondria are produced, and it is believed to delay the effects of aging and the onset of age-associated diseases. Aerobic exercise and caloric restriction are the two most compelling approaches to stimulate mitochondrial growth by activating the “master regulator” of mitochondrial growth and function known as PGC- 1α, a transcriptional coactivator. Dysregulation of PGC-1α has been implicated in aging and the development of numerous chronic diseases such as poor glucose control, increased fat mass with accompanying decrease in muscle mass, and various neurological conditions.*

PGC-1α-deficiency causes defects in energy metabolism, blood sugar regulation, and insulin action. These deficiencies also show reduced resistance to oxidative stress, increased fat mass, decreased muscle mass, impaired exercise performance, and other issues related to metabolic and physiological stress.  Conversely, PGC-1α activation contributes to an increase in metabolic fitness in the form of an increased metabolic rate, improved blood sugar regulation and insulin function, enhanced fatty acid oxidation, increased resistance to oxidative stress, decreased fat mass, and increased muscle mass and exercise performance.*

The nutrients in MitoCare have been clinically tested for their oral bioavailability and also for their safety and efficacy in activating PGC- 1α and upstream cellular signaling pathways. These actions mimic the protective effects of exercise and caloric restriction on mitochondrial growth, metabolic fitness, and aging. The key signaling cascades affected include those involving nitric oxide (Maximum ER™), SIRT1 (Longevity Formula™), and AMPK (LipoLean CR™). Ultimately, it is the stimulation of these cascades that leads to activation of PGC-1α and subsequent upregulation of mitochondrial biogenesis and promotion of overall metabolic fitness. For optimal benefit, combine this product with a healthy diet and exercise regimen.*