Support Liver

$28.00

  • Supports healthy liver function.
  • Protects the liver from toxic overload and cell damage.
  • Helps in energy production.
  • Aids the liver in the breakdown of toxins and metabolic waste.
  • Enhances the activities of detoxification enzymes.
  • Protects against free radical damage.
  • Resists against fatigue and malaise.
  • Contributes to improved filtration of blood.
  • May help to reduce discomfort caused by hepatic diseases.
  • Targets each phase of liver detoxification with specific essential nutrients.†

95 in stock (can be backordered)

SKU: Supp-Liv Category:

Product Description

  • Supports healthy liver function.
  • Protects the liver from toxic overload and cell damage.
  • Helps in energy production.
  • Aids the liver in the breakdown of toxins and metabolic waste.
  • Enhances the activities of detoxification enzymes.
  • Protects against free radical damage.
  • Resists against fatigue and malaise.
  • Contributes to improved filtration of blood.
  • May help to reduce discomfort caused by hepatic diseases.
  • Targets each phase of liver detoxification with specific essential nutrients.†

Three Capsules of Support Liver Contain:

Vitamin C (as Ascorbyl Palmitate) – 9 mg
Acts synergistically with N-Acetyl-Cysteine, assisting its active properties.1,2
L-Methionine – 300 mg
This sulfur-containing amino acid is the primary methylating agent in the liver. The importance of methylation cannot be overstated. Methylation is the biochemical process in which certain molecules transfer or donate a methyl group (-CH3) to other molecules. This donation of the one carbon molecule comes from larger molecules called methyl donors, such as methionine. Without the methylation process, methyl acceptors do not function optimally and damage to cellular structures can occur. Studies have demonstrated that impaired methylation can be detrimental to many functions in the human body, contribute to cardiovascular disease and arthritis, and may be the genesis of cancer. L-methionine is a powerful antioxidant, also assisting in the breakdown of fats and helping to inactivate free radicals. 3,4,5
Lemon Pure Form Bioflavonoid Complex – 450 mg 
Contains antioxidant properties that help maintain liver cell integrity and maximizes the effectiveness of the formula’s moderate vitamin C content. It is also helpful in maintaining the integrity of liver tissue. Bioflavonoids help to reduce inflammation and aid in tissue repair. 6,7
N-Acetyl-Cysteine – 150 mg
The effectiveness of N-Acetyl-Cysteine (NAC) is primarily attributed to its ability to reduce extracellular cystine to cysteine, or to act in the cells as a source of sulfhydryl groups. As a source of sulfhydryl groups, NAC stimulates glutathione synthesis and is capable of scavenging free radicals. The harmful compounds that are conjugated with glutathione then pass harmlessly out of the body through the biliary system. NAC is essential to empowering phase II liver detoxification’ sulfation process. 8,9,10
Taurine – 75 mg 
Taurine plays a major role in the liver via the formation of bile acids and detoxification. It is the major amino acid required for the removal of toxic chemicals and metabolites from the body and is an essential component of cell membranes, where it plays a role in stabilizing transport across cell membranes. A deficiency of taurine can lead to electrolyte imbalance due to impaired mineral transport across cell membranes and this reduces the ability of the liver to remove pollutants via the excretory routes of the bowel and kidneys. Many people with chemical sensitivities and allergies have abnormally low levels of taurine. The inclusion of taurine in Support Liver is beneficial for the above reasons as well as for the antioxidant protection it provides. 11,12,13
L-Glutathione (reduced) – 75 mg
The most abundant and required antioxidant in the body, glutathione (GSH) is synthesized from the amino acids glycine, L-cysteine, and glutamic acid. The level of glutathione in the liver is critically linked to the liver’s ability to detoxify. The higher the glutathione content, the greater the liver’s capacity to detoxify harmful chemicals. Typically, when we are exposed to chemicals which can damage the liver, the concentration of glutathione in the liver is substantially reduced. This reduction in glutathione renders liver cells susceptible to damage. Some glutathione is released directly by the liver into the bloodstream where it helps to maintain strong red blood cells while also protecting white blood cells. Glutathione acts as one of the major detoxifiers in the body, but it must be in the reduced form to work properly. Sometimes glutathione will be listed on the label of a product; however it won’t be listed as being ‘reduced’. The unreduced form is much cheaper and is not metabolically active. Support Liver uses the reduced form. 14,15,16

Suggested Use

General Suggestion: Three capsules ½ hour before breakfast.

References
  1. Schneider MP, Delles C, Schmidt BM, Oehmer S, Schwarz TK, Schmieder RE, John S. Superoxide scavenging effects of N-acetylcysteine and vitamin C in subjects with essential hypertension. Am J Hypertens. 2005 Aug;18(8):1111-7.
  2. Childs A, Jacobs C, Kaminski T, Halliwell B, Leeuwenburgh C. Supplementation with vitamin C and N-acetyl-cysteine increases oxidative stress in humans after an acute muscle injury induced by eccentric exercise. Free Radic Biol Med. 2001 Sep 15;31(6):745-53.
  3. Bombardieri G, Pappalardo G, et al. Intestinal absorption of S-adenosyl-l-methionine in humans. Int J Clin Pharm Ther Tox. 1983; 21:186-188.
  4. Kaye GL, Blake JC, Burroughs AK. Metabolism of exogenous S-adenosyl-L-methionine in patients with liver disease. Drugs. 1990; 40 (Suppl 3):124-128.
  5. Chawla RK, Bonkovsky HL, Galambos JT. Biochemistry and pharmacology of S-adenosyl-l-methionine and rationale for its use in liver disease. Drugs. 1990; 40 (Suppl 3): 98-110.
  6. Vinson JA, Bose P. Comparative bioavailability to humans of ascorbic acid alone or in a citrus extract. Am J Clin Nutr 1988;48:601-4.
  7. Kuo SM. Antiproliferative potency of structurally distinct dietary flavonoids on human colon cancer cells. Cancer Lett 1996;110:41-8.
  8. Matuszczak Y, Farid M, Jones J, Lansdowne S, Smith MA, Taylor AA, Reid MB. Effects of N-acetylcysteine on glutathione oxidation and fatigue during handgrip exercise. Muscle Nerve. 2005 Nov;32(5):633-8.
  9. N-acetyl cysteine, L-cysteine, and beta-mercaptoethanol augment selenium-glutathione peroxidase activity in glucose-6-phosphate dehydrogenase-deficient human erythrocytes. Clin Exp Med. 2004 Sep;4(1):50-5.
  10. Grinberg L, Fibach E, Amer J, Atlas D. N-acetylcysteine amide, a novel cell-permeating thiol, restores cellular glutathione and protects human red blood cells from oxidative stress. Free Radic Biol Med. 2005 Jan 1;38(1):136-45.
  11. Matsuda H, Kinoshita K, Sumida A, Takahashi K, Fukuen S, Fukuda T, Takahashi K, Yamamoto I, Azuma J. Taurine modulates induction of cytochrome P450 3A4 mRNA by rifampicin in the HepG2 cell line. Biochim Biophys Acta. 2002 Dec 16;1593(1):93-8.
  12. Benz C, Angermuller S, Otto G, Sauer P, Stremmel W, Stiehl A. Effect of tauroursodeoxycholic acid on bile acid-induced apoptosis in primary human hepatocytes. Eur J Clin Invest. 2000 Mar;30(3):203-9.
  13. Stipanuk MH. Role of the liver in regulation of body cysteine and taurine levels: a brief review. Neurochem Res. 2004 Jan;29(1):105-10. Review.
  14. Cascinu S, Cordella L, Del Ferro E, et al. Neuroprotective effect of reduced glutathione on cisplatin-based chemotherapy in advanced gastric cancer: a randomized double-blind placebo-controlled study. J Clin Oncol. 1995; 13:26-32.
  15. Novi AM. Regression of aflatoxin B1-induced hepatocellular carcinomas by reduced glutathione. Science. 1981; 212:541-542.
  16. Fernandez-Checa JC, Kaplowitz N. Hepatic mitochondrial glutathione: transport and role in disease and toxicity. Toxicol Appl Pharmacol. 2005 May 1;204(3):263-73. Review.

 

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